Tom and Jerry Meet Spider-Man and Venom be a Warner Bros. Pictures (WarnerMedia Byline), WB Animation, Metro-Goldwyn-Mayer Pictures and Marvel Studios.
The story begins with Tom, Jerry and Tuffy meet Spider-Man, MJ, Gwen Stacy, and Yuree Wadanee on a trip to San Franscesco. But the trip goes wild when they find Eddy Brock and find he's remained a host for Venom... and when they find there be more symbiotes including the feroscious Riot. The group must work together to stop Riot from leading a symbiote-invasion on Earth.
- Tom Cat -
- Jerry Mouse -
- Tuffy Mouse -
- Yuree Wadanabee: A police-lieutenant as well as a close ally to Spider-Man and co.
- Eddy Brock/Venom:
- Anne Weyeng/She-Venom: A police-captain on the San Fransesco Police and Eddy's girlfriend.
- Toodles Galore/She-Venom Cat: A police-captain cat on the San Fransesco Police and Tom's wife and girlfriend.
- Cherie Mouse/She-Venom Mouse: A police-captain mouse on the San Fransesco Police and Jerry's wife and girlfriend and Tuffy's aunt.
- Mr. Drake/Riot: A mad scientist who gains a symbiote called Riot.
- Richard Kind as Tom/Spider-cat
- Dana Hill as Jerry/Spider-mouse
- Kath Soucie as Tuffy/Spider-mouse Jr.
- Josh Keaton as Peter Parker/Spider-Man
- Mae Whitman as Mary Jane Watson/Spider-Woman
- Tara Strong as Gwen Stacey/Ghost-Spider
- Kelly Hu as Yuree Wadanabee.
- Troy Baker as Eddy Brock/Venom
- Eve Myles as Anne Weyeng/She-Venom
- Grey Griffin as Toodles Galore/She-Venom-cat
- Kari Wahlgren as Cherie/She-Venom-mouse
- Scott McNeil as Mr. Drake/Riot
- (upon seeing Eddy)
Tom: And I was enjoiny my day.
- Yuree Wadanabee: Eddy Brock!
Eddy Brock: What?
Tom: then whos..
Riot: Call us.. RIOT!
Jerry: Oh, boy.
- Spider-Man: So you thought it a grand idea to study symbiotes on a lab. A rash act which backfired, Colonel.
Spider-Woman: There's one on the lose. Riot!
Eddy Brock: We must go.
Venom: Aye. If he goes on the rocket, he'd bring more to Earth.
- Spider-Man: Why help us?
Venom: Eddy. And Anne. They....
MJ: Influence you.
- She-Venom: She-Venom's on the house.
- Spider-Man: Which be our chances?
Venom: Who knows? Riot's tough.
- Riot: Get on the rocket!
Venom: The world's ours. We refuse to let you destroy our home.
Riot: The host turned you soft. Then you would both suffer and die for your betrayal!
- Tom: Zoinks! And I thought Venom was fierce. Riot's more aggressive.
- Riot: You betrayed your own kind.
Spider-Man: Wrong. By conquering, you betrayed your own kind yourself.
- Rated PG (Parental Guidance) with moderate fantasy violence, mild threat, injury detail, horror.
- Suggested Running Times: 121 Minutes (NTSC), 116 Minutes (PAL).
- Tom's screw-up with the prawns be similar to a scene from Mr. Bean's Holiday.
- She-Venom says 'She-Venom's on the house'... a rephrase from a quote by Elves Presley.
- Tom says 'I got a terrible feeling on the moment'... a rephrase of a quote from the Star War franchise
- The Watcher says 'Blessings on you all.... you all who do good from bad and friends from foes'..... a rephrase of a quote from Shakespeare's Macbeth