Osmosis Jones II: The City of Frank

Osmosis Jones II: The City of Frank is a 2006 American live-action/animated action comedy film directed by Mike B. Anderson. It is the sequel to 2001's Osmosis Jones. Most of the cast reprised role, with the exceptions of Brandy Norwood, who were replaced by Cree Summer.

Plot
Ozzy and Drix became buddy police officers, their goal to protect a healthy lifestyle from any harm in the form of criminals, together, in the city of Frank DeTorre, who has already chosen a new profession to become a psychologist. Although they did not think about the safety of the city, the new mayor long ago tried to avoid an age crisis, Frank drank the energy drink Jolt Cola penetrating an ingredient into the body, a caffeine.

But by the time he met by the two idiot cops, Jolt was tamed as a new ally and the word "Peace" is attached to him. But if he gets separately of them, the city would be in danger, because caffeine had a goal to convert a heart attack, if possible Frank drinks too much. Will Osmosis Jones the white blood cell and Drixenol the pill be able to set the most important rules for this parasite?

Live/action characters

 * Bill Murray as Frank DeTorre
 * Ethan Cutkosky as Young Frank DeTorre (late-1960s)
 * Dane DeHaan as Young Frank DeTorre (late-1970s - 1980s)
 * Elena Franklin as Shane DeTorre
 * Michael J. Fox as William Jax, a manager and seller of "Copacabana" drinking store.
 * Tom Cruise as Jerry M. Caine
 * Michael J. Fox as William Jax, a manager and seller of "Copacabana" drinking store.
 * Tom Cruise as Jerry M. Caine
 * Tom Cruise as Jerry M. Caine

Animated characters

 * Chris Rock as Osmosis "Ozzy" Jones, an one of two protagonists.
 * David Hyde Pierce as Drixenol "Drix" Koldreliff, an one of two protagonists.
 * Jimmy Fallon as Jolt, a caffeine, but a former viral medication by ingredient from the same name product.
 * Harry Enfield as Kano Tade, a blood cell cancer, his hair is covered with a full color membrane also called a tumor.
 * Cree Summer as Leah Estrogen, a future Head of Brain Security, and early she was a cop too during before first meeting with Osmosis.
 * Don Novello as Nu Osmosis, an serious copy, when "if Ozzy would not join a 'Rusty Needle' gang".
 * Marc Vormawah as The Osmobile, also known as Backseat, the navigation and a talking car.
 * Marc Vormawah as The Osmobile, also known as Backseat, the navigation and a talking car.
 * Marc Vormawah as The Osmobile, also known as Backseat, the navigation and a talking car.
 * Marc Vormawah as The Osmobile, also known as Backseat, the navigation and a talking car.

Trivia

 * The Warner Bros.' first and last animated film with "Deep Canvas" technique.
 * Initially times after the premiere, the creators of this project could also filming the third part of the Osmosis Jones franchise.
 * Debut character's animator by Justin Hawthorn.
 * Bushington is a city where lives Helen Mars the first red blood cell cop, mentioned the two Presidents of US, George H. W. Bush and George Walker Bush. However, it is a city of George Walker Bush.
 * Full coloring on hair in the membrane not only called a tumor, this is associated either with the transformation from a cell to a parasite, or to a positive extent with the beauty of the lifestyle.

Transcript

 * Transcript here.