The Powerpuff Girls: The Movie: Generations

The Powerpuff Girls Movie 2: Generations is a 2024 American animated superhero musical film produced by the Warner Animation Group. The film is directed by series developers Nick Jennings and Bob Boyle, from a screenplay by Alicia Chan, Grace Kraft, and Jaydeep Hasrajani and a story by Jake Goldman, Haley Mancini, Eyal Podell, and Jonathon E. Stewart. A standalone sequel to The Powerpuff Girls Movie, it is based on The Powerpuff Girls created by Craig McCracken, the one-reel film Whoopass Stew by Craig McCracken, the 2014 special Dance Pantsed by David P. Smith, the anime Powerpuff Girls Z by Megumu Ishiguro, and the 2016 reboot developed by Nick Jennings and Bob Boyle. The film stars Amanda Leighton, Kristen Li, Natalie Palamides, Olivia Olson, Bill Hader, Zach Woods, Nick Kroll, Jennifer Hale, Kate Higgins, Tom Kenny, Roger L. Jackson, Cathy Cavadini, Tara Strong, and E.G. Daily. This film serves as the series finale of the 2016 reboot of The Powerpuff Girls, and is also the first installment of Warner Animation Group's Cartoon Network Cinematic Universe.

The Powerpuff Girls Movie 2: Generations was theatrically released on November 22, 2024 by Warner Bros. Pictures, in 2D, 3D, IMAX, IMAX 3D, RealD 3D, Dolby Cinema, and 4DX. The film received acclaim from critics, audiences, and fans of the original series, who praised the blend of live-action, traditional animation, and computer animation, style, voice acting, soundtrack, and musical numbers. Others considered it an inprovement over the 2016 reboot, and compared it favorably as a combination of Phineas and Ferb the Movie: Across the 2nd Dimension, Avengers: Endgame, Frozen II, Spider-Man: Into the Spider-Verse, and Teen Titans Go! vs. Teen Titans. It also crossed the billion dollar mark, grossing $2.798 billion against a budget of $90 million and became the highest-grossing film of 2024 and the highest-grossing film of all time. The Powerpuff Girls Movie 2: Generations won Best Animated Feature Film at the 82nd Golden Globe Awards, the 30th Critics' Choice Awards and the 97th Academy Awards, among several other awards and nominations. A sequel is in development.

The film is dedicated to Chuck McCann, voice of the Amoeba Boys in the classic series and 2016 reboot episode Viral Spiral, who died on April 8, 2018.

Synopsis
Blossom, Bubbles, and Buttercup have been saving Townsville for many years. But when a portal that the Professor recently invented starts malfunctioning, the Girls discover their past selves: the 1998-2005 Powerpuff Girls! To save their dimensions from being destroyed, they must team up with the 1998-2005 Girls to go through other dimensions, while also meeting their other past selves, such as the 2014 Girls, their 2006-2007 PPGZ's, and the 1992 Girls.

Plot
The film begins with a stage with the red curtains above. Bubbles thanks the audience for coming as she tells us that this is the story of how the Powerpuff Girls met their past selves and teamed up with them. She then starts reading the opening quotes (from the 1998-2005 series) on her paper. As she reads them, the curtains open to reveal a skyline of Townsville.

Powerpuff Girls Blossom (Amanda Leighton), Bubbles (Kristen Li), Buttercup (Natalie Palamides), and Blisstina Utonium (Olivia Olson) discover what it feels like to work together ("Townsville Is Where We Belong"), while also meeting up with Jared, Barry, the Derbytantes, and other classmates, as well as friendly Rowdyruff Boys Brick (Bill Hader), Boomer (Zach Woods), and Butch (Nick Kroll). The next day, Professor Utonium (Tom Kenny) invents a time portal and the Girls are amused. Afterwards, Amoeba Boys Bossman (DJ Khaled), Slim (Will Arnett), and Junior (Lil Rel Howery) break in and rewire the circuits of the portal, thus making it malfunction and start releasing the Powerpuff Girls' past selves.

On the way to school, Bubbles wanders around the streets, thinking about the important things in her lifetime ("Important Things In Life"). The Girls enter the school, and Bliss says that the school is really lit, as Blossom gets a crush on Jared. Buttercup asks Blossom if she's gonna talk to him, and Blossom tells her that she hasn't decided yet.

At lunch, Blossom talks to her sisters about the past of Townsville, in which she learned about. Bubbles tells Blossom that wisdom, humility, and honesty are the three things that she is looking for, even though she is the cute one. Brick, the leader of the friendly Rowdyruff Boys, calls Blossom, and he tells her that he found out about the other versions of the Powerpuff Girls. He also tells her that he got a footage of the Amoeba Boys tampering with the Professor's portal. At the Girls' table Bubbles tells Buttercup that the past comes before the present. Blossom later comes back to the table and tells Bubbles and Buttercup that there really are other versions of the Powerpuff Girls in main, parallel, and alternate universes.

Later, when the Girls got back from school, they discover that the portal had been malfunctioning. After trying to fix it, the portal inadvertently brings in their 1998 animated selves (Cathy Cavadini, Tara Strong, and E.G. Daily). They tell them that nothing is what is seems in all the dimensions, and that the now-powerful Giant Fishballoon (Kevin Michael Richardson) is coming back to destroy them. The next day, the six girls fly over to their school, only for Miss Keane (Jennifer Hale) to realize that there were six Powerpuff Girls in the school, leaving her confused. They then fly over to the Mayor’s office, only for the Mayor (Tom Kenny) to get confused about their differences and get his assistant Ms. Bellum to get them out. Back at home, the Professor is concerned about their differences and looks, as well as why the portal was malfunctioning, and tells the seven girls that their universes are getting destroyed. So he tasks the six girls to get more of their old selves to put together a team.

In their room, they think of a plan to stop the Fishballoon by joining forces with each other ("Getting The Team Together"). They later sneak into the Derbytantes' lair, thus sending the 1998 Girls to sneak up on Maylyn (Kate Higgins), who later discovers that there are two Buttercups, two Blossoms, and two Bubbleses. They later talk about why the portal had been malfunctioning. Bubbles tells the Derbytantes the story about how the Professor created them and how the Girls and Mojo Jojo became enemies after he filled all the primates with Chemical X, as well as how they were dubbed "The Powerpuff Girls". Once the seven Girls got home, the portal brings in the 2014 Girls (also Cathy Cavadini, Tara Strong, and E.G. Daily), who offer to help them with their mission.

Bliss shows them the Orb of Main, Parallel, and Alternate Universes (“A Beautiful Life”). The ten girls fly to different universes with a time machine: first the 1992 universe, then the 1998-2005 universe, the 2014 universe (“What We Did In The Past”), and finally the Powerpuff Girls Z universe.

Mojo Jojo, Fuzzy Lumpkins (Jim Cummings), Princess Morbucks (Haley Mancini), the Amoeba Boys (Arnett, Khaled, and Howery), the Gangreen Boys (Tom Kenny, Jeff Bennett), HIM (Sam Marin), Duplikate (Jill Talley), Bianca Bikini (Lily Vonnegut), Barbara Bikini, the Sporde (Ben Diskin), Silico (Jason Spisak), Gothra (Conrad Vernon), Sedusa (Kristen Wiig), Packrat (also Spisak), Bernie Bernstein (Tom Kenny), Manboy (Maurice LaMarche), the Broccoloids (Jeff Bennett), Chelsea (Kirby Howell-Baptiste), and the other villains all travel to the 1998-2005 dimension, and make a deal with the Fishballoon to defeat the Girls once they show up.

The Girls make it to the 2016 universe. They face Mojo and his gang, and try to battle him, but they are all outnumbered. Blossom tries to unleash the other versions of the Powerpuff Girls using the Orb of Alternate Universes, but the other Girls stop her from doing so. The villains easily defeat the Girls, sending them to the junkyard. After an argument between Bliss and 2016 Blossom, the Girls all split up.

2016 Bubbles gets heartbroken about what 2016 Blossom did to them and starts crying. 2016 Buttercup comforts her, and tells her that there's no end of friendship ("We Don't Want To Be Far Apart") and 2016 Bubbles feels better and hugs 2016 Buttercup, and then they went homeso 2016 Buttercup can watch a Space Tow Truck episode and 2016 Bubbles can go to sleep. She tells 2016 Buttercup good night and that she’ll see her tomorrow.

Meanwhile that night, a sad 2016 Blossom is sitting alone in the middle of the junkyard. She starts crying because of the argument she and Bliss had earlier. 1998 Blossom comes to her and tells her that it is never too late to do the right thing (“The Right Thing To Do”). Unfortunately, 2016 Princess Morbucks and her 1998 counterpart kidnap the Blossoms and takes them back to the 1998-2005 universe, sending them to Mojo Jojo’s lair. The next day, 2016 Bubbles wakes up to a new day, and finds a letter on Octi’s head, so she reads it, and in shock, she discovers that the Blossoms have been kidnapped, so she tells 2016 Buttercup about it, and then tell 1998 Bubbles and 1998 Buttercup about what happened, which discovered their Blossom has been kidnapped as well, and they all manage to tell Bliss about it.

The Bubbleses and Buttercups arrive and tell Bliss that the Blossoms have been kidnapped, and the other Powerpuff Girls arrive too. Bliss and the Girls fly to the 1998-2005 universe using the Powerpuff Time Machine. Meanwhile, 2016 Mojo Jojo reveals to the Blossoms that he is now working for 1998 Mojo Jojo. The Mojo Jojos activate the killing machine to start erasing the Blossoms forever. The Girls arrive and were gonna rescue the two from the machine. However, they refused to rescue the two after 2016 Buttercup told them about how 2016 Blossom insulted Bliss yesterday. So they all left the two behind and went back to their respective dimensions.

Later, they were all hanging out in Town Hall, but they were not happy. Bliss regrets denying the idea of unleashing Powerpuff Girls from other universes (“Selfless”), and realizes that Blossom was right: the best way to defeat them is to unleash the Powerpuff Girls of Infinite Earths, and 2016 Buttercup realizes how much of a jerk she was about what she said. Bliss tells the Girls that she has to unleash the Powerpuff Girls of Infinite Earths because that’s what 2016 Blossom always wanted, and then tells 2016 Buttercup that they have to go back to the 1998-2005 universe to rescue the Blossoms, and 2016 Buttercup agrees. They gathered everyone from their universes again after they went home from refusing to rescue 1998 Blossom and 2016 Blossom, and using the Powerpuff Time Machine, they went back to the 1998-2005 universe, but this time, they actually rescue the two from the machine. The Buttercups unplug the machine. 2016 Blossom and Bliss reconcile, and the Girls promise to work together, this time as a team, and fly back to the 2016 universe.

2016 Blossom gives up her leadership to Bliss, who uses the Orb of Main, Parallel, and Alternate Universes to form the “Powerpuff Girls of Infinite Earths”: the Powerpunk Girls, the Powerpup Girls, the Powerpuff Animals (Blossom as a walrus, Bubbles as a bee, and Buttercup as a flamingo), the 1920s Cartoon Girls, the dancing robotic Powerpuff Girls, the Powerpuff Girls Doujinshi (Rachel Matthews, Ariel Winter, and Jillian Bell), Bunny (Awkwafina), Bell (Kristen Bell), Bloom (Rachel Bloom), Bullet (Kate Micucci), and many other versions of the Girls. They easily overpower the Villains, and then, the Powerpuff Girls activate Dynamo to take out the bad guys. When Mojo Jojo and his crew have surrounded the Girls, the Professors from other universes, as well as the Rowdyruff Boys, the Derbytantes, and everybody else, come to their rescue, with the Derbytantes finally taking down the bad guys. Then, Mojo Jojo's evil primates arrive, but Bliss and 2016 Blossom work together to fight all the primates while singing Karmin’s “Brokenhearted”, joined by the 2016 Bubbles, 2016 Buttercup, the 1998 Girls, the 2014 Girls, the PPGZ girls, Professor Utonium, The Mayor of Townsville, Ms. Bellum, Maylyn, and the Rowdyruff Boys. The Girls finally defeat Mojo Jojo; however, 2016 Blossom sacrifices herself to defeat the Giant Fishballoon by plummeting him onto the ground, causing a huge explosion.

All of the Girls, including Bliss, Professor Utonium, Maylyn, and the Rowdyruff Boys look for 2016 Blossom until Bliss finds 2016 Blossom’s unconscious body. Bliss tries to wake 2016 Blossom up, but it was no use. Devastated, Bliss hugs and mourns over her sister, who wakes up, and reveals to Bliss and the others that the Fishballoon had already been shrunken, meaning that she has done what’s right. Bliss was happy that 2016 Blossom did the right thing, and 1998 Blossom says that she was proud of 2016 Blossom. Bliss then uses the Orb to send him to the Teen Titans GO! universe.

With the Townsvilles finally at peace, all of the Girls are sent home to their respective dimensions. Robin, Starfire, Beast Boy, Cyborg, Raven, and Bumblebee arrive and reveal to the Girls that The Fishballoon had tried to take over the Townsvilles, and Blossom knows the right location for it: the exact same zombie dimension that the Titans sent 2013 Trigon to (which he somehow escaped from). Raven opens a portal using her magic to send the Fishballoon there.

One week later, Townsville is no longer filled with crime, and the 2016 Powerpuff Girls are glad that they don’t have to endure another multiverse-threatening crossover for at least another year, and they make a promise to keep saving Townsville no matter what happens (“The Big Finale”). The narrator says “And so once again, with the help of all of their past selves and main, parallel, and alternate versions, the day is saved, thanks to: The Powerpuff Girls! You know, it’s not hard to know this is the end of the series. I guess I’ll cut it off here. Good night everyone!” And then the song ends and the curtains close ("American Girl"), ending the film and the series.

Main Characters

 * Amanda Leighton as 2016 Blossom
 * Kristen Li as 2016 Bubbles
 * Natalie Palamides as 2016 Buttercup, Barry Mackerbacker
 * Olivia Olson as Blisstina Francesa Francia Mariam Alicia Utonium
 * Toya Delazy voices Bliss in the African version, Wendy Ayche (Wengie) in the Australian version, and Alesha Dixon in the UK version
 * Bill Hader (replacing Rob Paulsen) as Brick
 * Zach Woods (replacing Rob Paulsen) as Boomer
 * Nick Kroll (replacing Roger L. Jackson) as Butch
 * Jennifer Hale as Ms. Keane and 1998 Princess Morbucks
 * Kate Higgins as Maylyn
 * Tom Kenny (replacing Tom Kane) as 2016 Professor Utonium, 1998 Professor Utonium, the Talking Dog, (reprising his role) the 2016 Mayor of Townsville, the 1998 Mayor of Townsville, The Narrator, and Mitch Mitchelson
 * Roger L. Jackson as 2016 Mojo Jojo, 2014 Mojo Jojo, and 1998 Mojo Jojo
 * Cathy Cavadini as 1998 Blossom and 2014 Blossom
 * Tara Strong as 1998 Bubbles and 2014 Bubbles
 * E.G. Daily as 1998 Buttercup and 2014 Buttercup
 * Jake Goldman as Jared Shapiro, Blossom’s love interest
 * Haley Mancini as 2016 Princess Morbucks
 * Will Arnett, DJ Khaled, and Lil Rel Howery (all replacing the late Chuck McCann) as the Amoeba Boys (Slim, Bossman, and Junior)
 * Kirby Howell-Baptiste as Chelsea
 * Jim Cummings as Fuzzy Lumpkins
 * Jill Talley as Duplikate
 * Jason Kaye as Gnat
 * Lily Vonnegut as Bianca Bikini
 * Fred Tatasciore (replacing Tom Kane) as 2016 HIM and 1998 HIM
 * Tatasciore also voices Nick LaNobodyKnows
 * Dee Bradley Baker as Barbarus Bikini
 * Ben Diskin as the Sporde
 * Maurice LaMarche as Pug-Faced Paulie, Manboy
 * Charlie Puth as Charlie    Chihuahua
 * Ty Dolla $ign as Dapper    Dan Doberman
 * Kendrick Lamar as Al    Cacone
 * Flo Rida as Poodles    Canoodles
 * Kenan Thompson as    Herman Shepherd
 * Wiz Khalifa as La Femme    Akita
 * Mike Mitchell as    Two-Tails Mulligan
 * Alex Hirsch as The    Butt-Sniffer
 * Ken Jeong as Mrs.    Gregory
 * Kathryn Hahn, Amy Sedaris,    and Chrissy Teigen as the Terrier Triplets
 * Jeff Bennett as the    Broccoloids, Janitaur
 * Jason Spisak as Silico,    Packrat
 * Daron Nefcy as Gothra
 * Kevin Michael    Richardson as the Giant Fishballoon
 * Kristen Wiig as Sedusa
 * Tom Kenny and Jeff    Bennett as the Gangreen Gang, whose names are Ace, Snake, Lil' Arturo,     Grubber, and Big Billy
 * Jennifer Fried as the Whoopass    Girls (archival recordings)
 * Nicole Bouma as Blossom    Akatsutsumi
 * Maryke Hendrikse as    Bubbles Gōtokuji
 * Kelly Metzger as    Buttercup Matsubara
 * Daran Norris, Eric    Bauza, John DiMaggio, and Mae Whitman as miscellaneous Townsville citizens
 * Josh Fadem as Donny the    Unicorn
 * Jennifer Lopez as Miss    Bellum
 * Yuri Lowenthal as    Townsville Citizen #1
 * Seth Green as    Townsville Citizen #2
 * Dwight Schultz as    Lester Van Luster
 * Fred Armisen as    Eyesosceles
 * Michael Rooker as    Tyrannosaurus Tex
 * Anais Fairweather as    Jemoire
 * Kyle A. Carrozza as    Harmadillo
 * Justin Roiland as    a Midway Elementary student
 * Phil LaMarr as    Townsville Citizen #3
 * Rob Paulsen as Rubber    Bandit/Townsville Citizen #4
 * James Arnold Taylor as    Townsville Citizen #5
 * Grey Griffin as    Townsville Citizen #6
 * Roger Craig Smith as    Schedulebot/Townsville Citizen #7/Bob LaGrange
 * Kath Soucie as a Midway    Elemendary student
 * Doug Nicholas as Townsville    Citizen #8
 * Becky G as Jaylyn/Bobbysuzeraelyn/Various    Derbytantes
 * Olivia Colman as Powerpuff Time Machine Computer Voice

Powerpuff Girls of Infinite Earths voices

 * Awkwafina (replacing the late Christine    Cavanaugh) as Bunny
 * Kristen Bell as Bell
 * Rachel Bloom as Bloom
 * Kate Micucci as Bullet
 * Alessia Cara as Bailey
 * Tina Fey as Banana
 * Charlyne Yi as Brownie
 * Kimaya Thais as Butterfly
 * Sophie Reynolds as Bouquet
 * Abbi Jacobson as Violet
 * Rachel Matthews as PPGD Blossom
 * Ariel Winter as PPGD Bubbles
 * Jillian Bell as PPGD Buttercup
 * TBA (formerly Chloe Bennet) as live-action    Blossom
 * Dove Cameron as live-action Bubbles
 * Yana Perrault as live-action Buttercup
 * Zendaya as Teenage Blossom
 * Kimiko Glenn as Teenage Bubbles
 * Sabrina Carpenter as Teenage Buttercup
 * Sugar Lyn Beard as 1920s Cartoon Powerpuff Girls    and 1930s dark and monochromatic Powerpuff Girls
 * Amanda Leighton as Walrus Blossom, Elderly    Blossom, the time-travel Blossoms from the Time Dasher, and Berserk
 * Kristen Li as Bee Bubbles, Elderly Bubbles, and    Brat
 * Natalie Palamides as Flamingo Buttercup, Elderly    Buttercup, and Brute
 * Olivia Olson as Blister, Vixen Bliss, and Elderly    Bliss
 * Cathy Cavadini, Tara Strong, and E.G. Daily as    the Steamypuff Girls and the Prehistoric Puff Girls
 * Eden Sher as Powerpup Girls (Puppy Blossom, Puppy    Bubbles, Puppy Buttercup, and Puppy Bliss) and Chickenpuff Girls (Chicken     Blossom, Chicken Bubbles, Chicken Buttercup, and Chicken Bliss)
 * Charli XCX as Bee
 * Dana Davis as Suzie
 * Abby Elliott as Belladonna
 * Kylie Cantrall as Bling
 * Joy of Red Velvet as Bleed
 * Yeri of Red Velvet as Beanie
 * Irene of Red Velvet as Blitz
 * Seulgi of Red Velvet as Beachball
 * Wendy of Red Velvet as Banshee

Teen Titans GO! Character Voices

 * Greg Cipes as Beast Boy
 * Scott Menville as Robin
 * Khary Payton as Cyborg
 * Tara Strong as Raven/Silkie
 * Hynden Walch as Starfire
 * Ozioma Akagha as Bumblebee
 * Kevin Michael Richardson as Trigon

Additional Voices

 * Frank Welker
 * Rob Paulsen
 * Josh Keaton
 * Trevor Devall
 * Crispin Freeman
 * Wally Wingert
 * Drake Bell
 * Candi Milo
 * Lacey Chabert
 * Kari Wahlgren
 * Lloyd Sherr
 * Fred Tatasciore
 * Jason Alexander
 * Janice Kawaye
 * Seth MacFarlane
 * Carolyn Lawrence
 * Carlos Alazraqui
 * Jessica DiCicco
 * Laraine Newman
 * Tom Kenny
 * Ben Schwartz
 * Debi Derryberry
 * Audrey Wasilewski
 * Nika Futterman
 * Tara Strong
 * Edgar Wright
 * Wes Anderson
 * Nolan North
 * Jess Harnell
 * Mark Hamill
 * Rachael MacFarlane
 * Adam DeVine
 * Flula Borg
 * S. Scott Bullock
 * Fred Tatasciore
 * Tress MacNeille
 * Andy Richter
 * Jess Harnell

In the UK version, Kate Garraway and Ben Shephard replace Bob LaGrange and Nick LaNobodyKnows in the news report scene.

The villains from Powerpuff Girls Z appear without any dialogue.

Mojo Jojo’s evil primates, including Rocko Socko, Ojo Tango, Hotta Watta, and Killa Drilla, appear as well, with Frank Welker, Kevin Michael Richardson, and Rob Paulsen reprising their roles from The Powerpuff Girls Movie (2002), although The Powerpuff Girls Movie 2: Generations would be a standalone sequel to The Powerpuff Girls Movie (2002).

Development
After Warner Animation Group and Cartoon Network started development on films for a shared Cartoon Network universe, developers Nick Jennings and Bob Boyle announced a sequel to The Powerpuff Girls Movie for November 2024. This resulted in the 2016 reboot of The Powerpuff Girls being brought back for three more seasons, which weere Seasons 4, 5, and 6, but all cringe and outdated memes are removed and are all replaced with musical numbers, a lot of heart, and heartwarming messages. Seasons 4-6 will have 1 or 2 songs for each episode. If it’s a double length episode, then it will have 3 songs. In Seasons 4, 5, and 6, Blossom redeemed herself back to being an intelligent, dutiful, and kind-hearted leader and abandoned her “stereotypical, bratty, and mean-spirited” personality, Bubbles redeemed herself back to being the sweet and cheerful member of the four, while also having an amazing singing voice, a kind heart, and a passion to grow up to become old and wise, and of course, she also abandoned her “psychotic, annoying, goody-two-shoes crybaby” personality, Buttercup abandoned her “complete bully” personality, banished all “butt-jokes” from her life forever, and redeemed herself into a tough but friendly model to her family and friends, and Blisstina appeared in more episodes of the reboot in Seasons 4-6, as she resigned as the member of the Universal Protection Bureau so that she will spend more time with her sisters and fight crime and save Townsville alongside them; she also attends school with them. One of the other additions to this reboot is Blisstina has her own bedroom, with a front doorway that leads straight to the Girls’ bedroom. The original songs for Seasons 4-6 of the 2016 reboot of The Powerpuff Girls will be written by The LEGO Movie 2: The Second Part songwriter Jon Lajoie. The soundtrack album for the reboot was available on WaterTower Music. Seasons 4-6 will also mark the return of Sedusa and Ms. Bellum, who were voiced by Kristen Wiig and Jennifer Lopez respectively.

The first episode of Season 4 focused on Blossom, Bubbles, Buttercup, and Professor Utonium giving Bliss a new room, after she quit the UPB to spend time with her family, and the second featured the Rowdyruff Boys redeeming themselves and becoming friends with the Powerpuff Girls after apologizing for all the things they did to them in the classic 1998 series. The Narrator also returned from Season 4 onward. Bill Hader, Zach Woods, and Nick Kroll voiced Brick, Boomer, and Butch respectively in Seasons 4-6, The LEGO Movie 3: A Powerpuff Adventure, The Powerpuff Girls Movie 2: Generations, and the follow-up series The Powerpuff Girls: Tales from the City of Townsville. The fifth season finale episode takes place before the events of The LEGO Movie 3: A Powerpuff Adventure, and the sixth and final season takes place between the events of The LEGO Movie 3: A Powerpuff Adventure and The Powerpuff Girls Movie 2: Generations, making the original 2016 reboot end after Season 6 and the film. These seasons were in tandem with the live-action reboot of The Powerpuff Girls on The CW. Seasons 4-6 had 1 or 2 songs for each episode. If it’s a double length episode, then it was 3 songs.

Animation
The traditional 2D animation was handled by South Korean animation studios Sunmin Image Pictures (2016 Powerpuff Girls) and Rough Draft Korea (1998 Powerpuff Girls) for Cartoon Network Studios in Burbank, California, while CGI animation for the 2014 Powerpuff Girls was handled at British CGI animation studio Passion Pictures, and the anime-style animation for the Powerpuff Girls Z characters was handled at Japanese animation studio Toei Animation, while the live-action versions of The Powerpuff Girls (from the CW live-action reboot) were recorded in Georgia, which they were put in green screens, and edited in. The animation for the LEGO Powerpuff Girls was provided by Animal Logic, while the animation for the Funko Powerpuff Girls was provided by Funko Animation Studios. The animation for the Teen Titans Go! characters was handled at Bardel Entertainment in Canada. Like Space Jam: A New Legacy, the film was a combination of live-action, traditional animation, and computer animation.

Casting
On June 19, 2023, Amanda Leighton was cast as 2016 Blossom. This was followed by the casting announcements of Kristen Li, Natalie Palamides, Olivia Olson, Bill Hader, Zach Woods, Nick Kroll, Jennifer Hale, Kate Higgins, Tom Kenny, Roger L. Jackson, Cathy Cavadini, Tara Strong, and E.G. Daily the next day. On the same day, Tom Kenny confirmed that he will be voicing 2016 Professor Utonium, 1998 Professor Utonium, and the Talking Dog, replacing Tom Kane following his retirement from voice acting. Fred Tatasciore also replaces Kane as 2016 HIM and 1998 HIM.

Songs written by John Debney, Glen Ballard, Carole Bayer Sager, and Linda Thompson

 * Townsville Is Where We Belong - Amanda Leighton, Kristen Li, Natalie Palamides, Olivia Olson, Bill Hader, Zach Woods, Nick Kroll, and The Powerpuff Girls Movie 2 Cast (sung by Blossom, Bubbles, Buttercup, Bliss, Brick, Boomer, Butch, and the Townsville citizens; parody of “Some Things Never Change” from Frozen II)
 * Important Things In Life - Kristen Li (parody of “When I Am Older” from Frozen II)
 * Getting The Team Together - Amanda Leighton, Kristen Li, Natalie Palamides, Olivia Olson, Cathy Cavadini, Tara Strong, and E.G. Daily (sung by the 1998-2005 Powerpuff Girls, the 2016 Powerpuff Girls, and Bliss; parody of “When Will My Life Begin” from Tangled)
 * A Beautiful Life - Olivia Olson (parody of “Rewrite The Stars” from The Greatest Showman)
 * What We Did In The Past - Cathy Cavadini, Tara Strong, and E.G. Daily (this is sung by the 1998-2005 and 2014 versions of the Powerpuff Girls; parody of “Waving Through A Window” from Dear Evan Hansen)
 * We Don't Want To Be Far Apart - Kristen Li and Natalie Palamides (parody of “I See The Light” from Tangled)
 * The Right Thing To Do - Amanda Leighton and Cathy Cavadini (sung by 1998 Blossom and 2016 Blossom; parody of “Show Yourself” from Frozen II)
 * Selfless - Olivia Olson (parody of “Speechless” from the 2019 remake of Aladdin)
 * The Big Finale - Amanda Leighton, Kristen Li, Natalie Palamides, Olivia Olson, Bill Hader, Zach Woods, Nick Kroll, Kate Higgins, Jennifer Hale, Tom Kenny, and Jake Goldman (a finale reprise of "Townsville Is Where We Belong" with excerpts of "What We Did In The Past", "A Beautiful Life", and "The Right Thing To Do")

End Credits Songs

 * American Girl - Bonnie McKee
 * Me & My Girls - Fifth Harmony
 * Who’s Got The Power? - Tacocat
 * The Powerpuff Girls Movie 2: Generations End Credits Music - John Debney

Bonus Songs

 * Talk To Me - Carly Rae Jepsen
 * Both Sides Now - Carly Rae Jepsen
 * Power Up - Red Velvet
 * CAKE - Wengie
 * Deja Vu - Wengie
 * TALK TALK - Wengie, David Amber
 * TALK TALK (Japanese Version) - Wengie, eill, David Amber

Instrumental Tracks

 * Townsville Is Where We Belong (Instrumental) – John Debney, Glen Ballard, Carole Bayer Sager, Linda Thompson
 * Important Things In Life (Instrumental) – John Debney, Glen Ballard, Carole Bayer Sager, Linda Thompson
 * Getting The Team Together (Instrumental) – John Debney, Glen Ballard, Carole Bayer Sager, Linda Thompson
 * A Beautiful Life (Instrumental) – John Debney, Glen Ballard, Carole Bayer Sager, Linda Thompson
 * What We Did In The Past (Instrumental) – John Debney, Glen Ballard, Carole Bayer Sager, Linda Thompson
 * We Don't Want To Be Far Apart (Instrumental) – John Debney, Glen Ballard, Carole Bayer Sager, Linda Thompson
 * The Right Thing To Do (Instrumental) – John Debney, Glen Ballard, Carole Bayer Sager, Linda Thompson
 * Selfless (Instrumental) - John Debney, Glen Ballard, Carole Bayer Sager, Linda Thompson
 * The Big Finale (Instrumental) – John Debney, Glen Ballard, Carole Bayer Sager, Linda Thompson
 * American Girl (Instrumental) – Bonnie McKee
 * Me & My Girls (Instrumental) – Fifth Harmony
 * Who’s Got The Power? (Instrumental) – Tacocat

Score tracks by John Debney


 * 1) The City of Townsville - John Debney
 * 2) The Portal - John Debney
 * 3) Amoeba Boys - John Debney
 * 4) 1998 Girls - John Debney
 * 5) Sneaking Into The Derbytantes' Lair - John Debney
 * 6) Maylyn / Bubbles' Recap - John Debney
 * 7) 2014 Girls - John Debney
 * 8) Blisstina - John Debney
 * 9) Time Travel - John Debney
 * 10) Mojo Jojo - John Debney
 * 11) Arrival To The 1992 Universe - John Debney
 * 12) This Is Our Room - John Debney
 * 13) Tokyo City / New Townsville - John Debney
 * 14) Return To 2016 Townsville - John Debney
 * 15) Trying To Defeat Mojo Jojo / The Plan Backfires - John Debney
 * 16) Don’t You Realize What You’ve Done? /The Powerpuff Girls Split Up - John Debney
 * 17) A Lonely Purpose - John Debney
 * 18) 1998 Blossom and 2016 Blossom – John Debney
 * 19) Blossoms Kidnapped - John Debney
 * 20) Bliss Gets A Warning from the Girls – John Debney
 * 21) Two Mojo Jojos – John Debney
 * 22) Save It For The Jury, Bloss – John Debney
 * 23) Townsville Hall / Sad Bliss / Guilty Buttercup – John Debney
 * 24) Back to the 1998-2005 Universe – John Debney
 * 25) Rescuing The Blossoms / 2016 Blossom and Bliss Reconcile - John Debney
 * 26) The Powerpuff Girls of Infinite Earths - John Debney
 * 27) Final Battle - John Debney
 * 28) The Townsvilles Are Saved - John Debney
 * 29) Teen Titans – John Debney
 * 30) A Promise To Keep Saving Townsville - John Debney

Remixes of Bonnie McKee's "American Girl"


 * American Girl (DJ Linuxis Remix) - Bonnie McKee
 * American Girl (Steve Aoki Remix) - Bonnie McKee
 * American Girl (Liam Walds Remix) - Bonnie McKee
 * American Girl (Oliver Remix) - Bonnie McKee
 * American Girl (Acoustic Version) - Bonnie McKee

Songs featured in the movie


 * Wonderful Life (Mi Oh My) (from “The Angry Birds Movie”) - Matoma
 * True - Spandau Ballet
 * Life of the PRTY - PRTY H3RO
 * My Heart Will Go On (Love Theme from "Titanic") - Kenny G
 * On Top of the World - Imagine Dragons
 * GDFR - Flo Rida, Sage The Gemini, LooKas
 * TALK TALK (Japanese Version) - Wengie, eill, David Amber
 * Portals (from “Avengers: Endgame”) - Alan Silvestri
 * Butter - BTS
 * Tonight I'm Getting Over You - Carly Rae Jepsen
 * Battle Royale (from “The LEGO Batman Movie”) - Lorne Balfe
 * Brokenhearted - Karmin

Songs from the trailers

 * Let's Go - Tiësto, Icona Pop (Teaser Trailer; TV Spots)
 * Do It Like This - Daphne Willis (Official Trailer 1; International Trailer; Final Trailer; TV Spots)
 * Watch Me – Jaden Smith (Official Trailer 1; Official Trailer 2; Official Trailer 3; International Trailer; Final Trailer; TV Spots)
 * Who’s Got The Power? - Tacocat (Official Trailer 2; TV Spots)
 * Confident - Demi Lovato (International Trailer; TV Spots)
 * Ho Ho Ho - Sia (Christmas TV Spots)

Release
The film was theatrically released in North America and the Philippines on November 22, 2024 in 2D, 3D, IMAX, IMAX 3D, RealD 3D, Dolby Cinema, and 4DX.

A teaser trailer was released online on October 1, 2023. The film’s first official trailer was released on April 3, 2024. It was followed by a second trailer on July 1, 2024, and one month later, the third was released on August 10, 2024, until then an intranational trailer came out on August 31, 2024. The final trailer was released was released on September 27, 2024.

Marketing tie-ins
The brands that partnered with The Powerpuff Girls Movie 2: Generations include McDonald's for Happy Meal toys, Coca-Cola, Nestlé, and Kellogg's for their breakfast cereals, Unilever and Frito-Lay for all their worldwide brands, PureFoods for Tender Juicy Hotdog brands, Smart Communications, Inc., Oreo Cookies, Chips Ahoy!, Tic Tac, Xfinity, Dish Network, DIRECTV (Satellite), and Sky UK. LEGO sets were also made to promote the film. The Funko POP! Figures will be the same as the original ones, but with Blisstina Utonium and Jared Shapiro added.

Spin Master reproduced the 8” Blossom, Bubbles, and Buttercup plush toys, with a new 8” Bliss plush added. They also manufactured several playsets based on the film.

There was also a game app based on the film alongside Warner Bros. Games, Warner Bros. Interactive Entertainment, and Cartoon Network Games.

There was also an Angry Birds Friends tournament as a promotional tie-in for the film. The tournament is called Angry Birds Friends X The Powerpuff Girls Movie 2: Generations. Players can launch the birds, destroy the cages, pop the pigs, and free the main, parallel, and alternate versions of the Powerpuff Girls.

Devsisters Corporation partnered with Warner Bros. to collaborate Cookie Run: Kingdom with The Powerpuff Girls Movie 2: Generations. The collaboration served as a promotional tie-in for the film.

There were also two lyric videos for “American Girl” by Bonnie McKee and “Me & My Girls” by Fifth Harmony, both are which are from The Powerpuff Girls Movie 2: Generations. Both were on all of the Warner Bros. YouTube channels worldwide. The music videos for these two songs were edited and features clips from The Powerpuff Girls Movie 2: Generations.

SuperMarioLogan made a deal with Warner Bros. to produce a new SML movie for YouTube featuring Blossom, Bubbles, Buttercup and Bliss to promote The Powerpuff Girls Movie 2: Generations. Amanda Leighton, Kristen Li, Natalie Palamides, and Olivia Olson made a guest appearance in the SML movie, reprising their roles as plush versions of Blossom, Bubbles, Buttercup, and Bliss.

There was also an exclusive The Shop: Uninterrupted featurette featuring LeBron James, Maverick Carter, Blossom, Bubbles, Buttercup, and Bliss. In the clip, Blossom, Bubbles, Buttercup and Bliss discuss The Powerpuff Girls Movie 2: Generations with LeBron and Maverick.

Short film
The film's theatrical release was preceded by a LEGO Movie short film titled Santa’s Little Helpers: A LEGO Movie Short. In the short film, Emmet and his Master Builder friends, Wyldstyle, Unikitty, Benny, and MetalBeard, having accidentally arrived at the North Pole, make the most of the situation by trying to become elves.

The short film stars the voices of:


 * Chris Pratt as Emmet
 * Elizabeth Banks as Wyldstyle
 * Alison Brie as Unikitty
 * Charlie Day as Benny
 * Nick Offerman as MetalBeard
 * James Adomian as Head Elf
 * Tom Kenny as Santa Claus
 * Eden Sher as Baby Reindeer
 * Alan Tudyk as Adult Reindeer
 * Dana Davis, Eden Sher, and Alan Tudyk as Elves

The short's running time is 4 minutes, and its end credits song is "Everything Is Awesome (Christmas Remix)" by Jo Li.

Home Media
The film was released on Digital HD on February 22, 2025, and on Ultra HD Blu-ray, Blu-ray 3D, Blu-ray and DVD on March 4, 2025 by Warner Bros. Home Entertainment. It includes deleted scenes, the filmmakers commentary, the "Behind-The-Puffs" featurette, the outtakes, the nine digital shorts from Seasons 1 and 2 of the 2016 reboot (Air Buttercup, Bubbles' Beauty Blog... but on Video, Run Blossom Run, Ping Pong Z, Bubbs & Donny Get the Mail, Bedtime, Mojo Builds a Shelf, I’ll Be Bake, and Blissfully Unaware), the LEGO Movie short Santa’s Little Helpers, a sing-along version, and a teaser trailer for 2025's Storks 2. It was also included in the Powerpuff Girls Complete Series DVD along with The LEGO Movie 3: A Powerpuff Adventure.

Alongside The LEGO Movie 3: A Powerpuff Adventure, the film was also released as an HBO Max offering and a WarnerUniversal All Access launch title on May 28, 2025, the same day the streaming service launched, and the same day the follow up series, spin-offs, and original series premiered on aforementioned streaming service, HBO Max, and Cartoon Network.

Box Office
The Powerpuff Girls Movie 2: Generations grossed $858.3 million in the United States and Canada, and $1.939 billion in other territories, for a worldwide total of $2.798 billion, becoming the highest-grossing film of all time in the United States and Canada. It is the fifth-highest-grossing film of all time worldwide.

The film had a worldwide opening of $1.2 billion. It was also the fastest film ever to eclipse the $1 billion and $1.5 billion mark, doing so in just five days and eight days, respectively. Deadline Hollywood estimated the film would break even just five days after its release, which is "unheard of for a major studio tentpole during its opening weekend". The website eventually calculated the final net profit of the film to be $890 million, accounting for production budgets, marketing, talent participations, and other costs, with box office grosses, and ancillary revenues from home media, placing it first on their list of 2024's "Most Valuable Blockbusters".

On May 4, the film's earnings at the global box office became the fastest film ever to gross $2 billion worldwide, amassing the amount in only 11 days. It also became the fifth film to surpass this threshold, and the second film to surpass the threshold of $2.5 billion, doing so in just 20 days.

United States and Canada
The Powerpuff Girls Movie 2: Generations set the records on Fandango for most tickets sold by an animated film in that frame. The film was projected to gross $200–250 million domestically during its opening weekend, although some insiders saw those figures as conservative and expected a $260–300 million debut. By the week of its release, domestic estimates had risen to $260–270 million, with some insiders still suggesting a $300 million debut was possible. The film played in 4,662 theaters, 410 of which were in IMAX. The Powerpuff Girls Movie 2: Generations earned $357.1 million in its opening weekend. It also set records for Friday ($157.5 million, including $60 million from Thursday night previews), Saturday ($109.3 million), and Sunday ($90.4 million) totals, as well as was more of a total gross alone than the previous box office high of all films combined ($314 million). The film then made $36.9 million on Monday and $33.1 million on Tuesday, both the third-highest of all time. In its second weekend the film made $147.4 million (the second-best sophomore frame ever) for a 10-day total of $621.3 million. It was the fastest film to ever pass the $600 million milestone. The following week, the film grossed $64.8 million, the fourth-best third weekend ever. It also passed the $700 million mark. It made $17.2 million the following weekend (and a total of $22.3 million over the four-day Memorial Day frame), crossing the $800 million threshold domestically. During the re-release, which occurred over its tenth weekend, the film was added to 1,040 theaters and made $6.1 million, an increase of 207% from the previous weekend. In its thirteenth weekend the film made $1.2 million.

Other territories
Internationally, The Powerpuff Girls Movie 2: Generations was projected to gross around $680 million over its first five days for a global debut of $850–950 million. The film was initially projected to gross $250–280 million in China in its opening weekend, but made a record $107.5 million (RMB 719 million) in the country on its first day, including $28.2 million (RMB 189 million) from midnight, 3 AM and 6 am screenings. Due to the record-breaking first day, partnered with word of mouth (with a 9.1 on local review aggregator Douban and a 9.3 on ticket website Maoyan), debut projections were increased to over $300 million. Overall, the film made $169 million on the first day from international countries, the highest total of all time. Its largest markets after China were India ($9 million), South Korea ($8.4 million; the largest non-holiday single day gross ever), Australia ($7.1 million), France ($6 million), and Italy ($5.8 million). Like domestically, the film ended up over-performing and debuted to $866 million overseas. Its largest markets, every one of which set the record for best-ever opening in the country, were China ($330.5 million; RMB 2.22 billion), the United Kingdom ($53.8 million), South Korea ($47.4 million), Mexico ($33.1 million), Australia ($30.8 million), Brazil ($26 million), Spain ($13.3 million), Japan ($13 million), and Vietnam ($10 million). It also made $21.6 million over its first four days in Russia after a delay of its premiere that was caused by the Russian government.

In its first week, the film's top five largest international markets were China ($459.4 million), the United Kingdom ($68.2 million), South Korea ($60.3 million), Mexico ($48.6 million), and India ($40.9 million). A week after its release, it became the highest-grossing foreign film of all time in China and India. In its second weekend the film's running total passed $1.569 billion from international markets.

The film's top international markets were China ($629 million), United Kingdom ($115 million), South Korea ($105 million), Brazil ($86 million), and Mexico ($78 million).

Critical response
On review aggregation website Rotten Tomatoes, the film holds an approval rating of 100% based on 421 reviews, with an average rating of 10/10. The website's critics consensus reads, "Heartwarming, funny, beautifully animated, and filled with returning voice actors, returning characters, and musical numbers, The Powerpuff Girls Movie 2: Generations really does have the power and brings the family together." Metacritic, which uses a weighted average, assigned the film a score of 84 out of 100 based on 57 critics, indicating "universal acclaim." Audiences polled by CinemaScore gave the film an average grade of "A+" on an A+ to F scale, while those at PostTrak gave it an overall positive score of 100%, a 100% "definite recommend," and a 5 star rating.

The film received a four-star rating from Matt Zoller Seitz of RogerEbert.com, who wrote, "This film is a massive improvement over the 2016 reboot, as there is no cringe in this film." The Washington Post's Ann Hornaday also gave the film 5 out of 5 stars and praised its, "visually dazzling concoction of wily schemes and daring adventures", as well as achieving, "a continuation of Cartoon Network's theatrical reputation." Peter DeBruge of Variety wrote, "The Powerpuff Girls Movie ushered in the era of traditionally animated cartoon features, and this sequel wraps up the saga beautifully. At least, for now." The Daily Telegraph 's Robbie Collin wrote, "The Powerpuff Girls Movie 2 reaffirms that the Warner Animation Group, at their best, are like no other animation studio around." Writing for Variety, Peter Debruge wrote, "The 2016 Girls have been improving on their singing, and their 1998 counterparts gave them the power again. This film wins back what made the original series special."

The film also gained lots of positive feedbacks from fans of the original series, with one saying "This film is a massive improvement over the 2016 reboot. Warner Animation Group should make more animated films based on the 2016 reboot, while Cartoon Network should reboot the 1998 series and make it continue where the original left off." Another fan of the original series wrote, "Warner Animation Group should continue the adventures of Blossom, Bubbles, Buttercup, and Bliss."

Accolades
The Powerpuff Girls Movie 2: Generations won Best Animated Feature Film at the 82nd Golden Globe Awards, and won the same award at the 30th Critics' Choice Awards and the 97th Academy Awards, among several other awards and nominations. The film appeared on many critics' top ten lists. According to Metacritic it appeared in first place on 5 lists. Critics at New York Magazine listed it at 9 on their list of the best films of the decade.

Trivia

 * Warner Animation Group was not involved with the first Powerpuff Girls Movie.
 * The first installment of Warner Animation Group's Cartoon Network Cinematic Universe.
 * The first time the 2016 reboot got a feature film.
 * It is revealed that the 1998 Powerpuff Girls and 2016 Powerpuff Girls are from separate universes.
 * Nick Jennings and Bob Boyle replace Craig McCracken from the first film, though McCracken serves as one of the executive producers of the film.
 * John Debney replaces James L. Venable from the first film.
 * Brick is the fourteenth character for Bill Hader to voice, after Sam the Soldier from Doogal (2006), the Gazelle from Ice Age: Dawn of the Dinosaurs (2009), Flint Lockwood from Cloudy with a Chance of Meatballs (2009) and its 2013 sequel, Hansel from Hoodwinked Too! Hood vs. Evil (2011), Guy Gagné from Turbo (2013), Fear from Inside Out (2015), King Leondard Mudbeard from The Angry Birds Movie (2016) and its 2019 sequel, Stan from Finding Dory (2016), Firewater, Tequila, and El Guaco from Sausage Party (2016), Axel the Carnie from Toy Story 4 (2019), and Cyrus Strange from The Addams Family 2 (2019).
 * Boomer is Zach Woods' third animated character after Zane from The LEGO Ninjago Movie (2017) and Carl Eagle from The Angry Birds Movie 2 ( 2019).
 * Butch is Nick Kroll's sixth animated character after Douche from Sausage Party (2016), Gunter from Sing (2016) and its 2021 sequel, Professor Poopypants from Captain Underpants: The First Epic Movie (2017), Happy Sergei from The Secret Life of Pets 2 (2019), and Uncle Fester from The Addams Family (2019) and its 2021 sequel.
 * The feature debut of the Rowdyruff Boys.
 * The film serves as the series finale of the 2016 reboot.
 * The narrator never says "The City of Townsville" at the beginning of the movie, but Bubbles reads these words on the papers before the curtains even open.
 * The Teen Titans recall the events of TTG v PPG.
 * The scene where 2016 Blossom and Bliss sang "Brokenhearted" by Karmin while fighting off Mojo Jojo's evil primates is similar to the scene where Katie Mitchell and Rick Mitchell sang "Live Your Life" by Rihanna and T.I. while fighting off the PAL Max Prime robots from the 2021 Netflix and Sony Pictures Animation film The Mitchells vs. the Machines.
 * The Powerpuff Time Machine is the third character for Olivia Colman to voice in animated film, after PAL from The Mitchells vs. the Machines (2021) and Donka from Ron's Gone Wrong (2021).
 * Violet is Abbi Jacobson's third animated character after Nya from The LEGO Ninjago Movie (2017) and Katie Mitchell from The Mitchells vs. the Machines (2021).
 * Bunny is Awkwafina's sixth animated character after the Quail from Storks (2016), Courtney from The Angry Birds Movie 2 (2019), Otto from The SpongeBob Movie: Sponge on the Run (2020), Sisu from Raya and the Last Dragon (2021), and Ms. Tarantula from The Bad Guys (2022).
 * Bloom is Rachel Bloom's fourth animated character after Silver from The Angry Birds Movie 2 (2019), Queen Barb from Trolls World Tour (2020), and Op from Extinct (2021).
 * This is also the first time The Powerpuff Girls (2016) is PAL pitched in some countries, as when the series aired, the pitch remained the same.
 * The live-action Powerpuff Girls have been transported to the animated 2016 universe during the final battle.
 * This film premiered the day exactly 5 years after Frozen II (2019) released theatrically.
 * While The LEGO Movie 3: A Powerpuff Adventure took place between the fifth season and the sixth and final season of the 2016 reboot of The Powerpuff Girls, this film took place after the sixth and final season.

Cameo appearances

 * Both the 2019 Warner Bros. logo and the 2021 Warner Animation Group logo appeared as easter eggs in this film:
 * They appeared on a chart that 2016 Blossom showed the Girls' past selves in the "Getting The Team Together" song sequence.
 * They appeared again as constellations throughout the "A Beautiful Life" song sequence.
 * They appeared again on two of the mirrors when the two Blossoms were singing the last lyrics of "The Right Thing To Do".


 * An image of Ultrakatty from The LEGO Movie 2: The Second Part is seen on one of the lockers.
 * Migo, Meechee, Gwangi, Fleem, and Kolka from Smallfoot can be seen as plush toys in the Powerpuff Girls’ room.
 * Diamond Destiny from Storks is seen on a baby carriage when Bubbles sings "Important Things In Life".
 * Wolf Pack leaders Alpha and Beta from Storks appear as bobbleheads on one of the vehicles.
 * Krypto, Ace, Chip, Merton, and PB from DC League of Super-Pets make a cameo on a sidewalk.
 * A Townsville citizen wears the same robe as the Stonekeeper.
 * Harley Quinn's mallet from The LEGO Batman Movie is seen inside one of the lockers.
 * The Ultimate Ultimate Weapon chest from The LEGO Ninjago Movie made a cameo appearance in the Girls' closet.
 * A poster for The LEGO Movie 2: The Second Part is seen at the back of the bus.
 * Blue Falcon (Brian) and Dynomutt appear as two figurines among Bubbles’ 3D printed models of the Space Tow Truck characters.
 * Pigeon Toady appears a figurine in the Powerpuff Girls’ room.
 * LeBron James from Space Jam: A New Legacy makes a cameo appearance as a bobblehead in the school bus.
 * Butch from Tom & Jerry can be seen in a "Hang In There, Baby" poster.
 * Emmet, Wyldstyle, Unikitty, Benny, MetalBeard, Batman, and Vitruvius from The LEGO Movie can be seen as regular LEGO figures among Bubbles’ 3D printed models of the Space Tow Truck characters.
 * Wile E. Coyote and the Road Runner from Coyote vs. Acme make a cameo appearance in another scene during the “Townsville Is Where We Belong” song sequence.
 * The books The Cat in the Hat, Oh, the Places You'll Go!, The Ice Dragon, Toto, The Dog-Gone Amazing Story of The Wizard of Oz, Wed Wabbit, and That Christmas appear in a bookshelf.
 * Rex Dangervest from The LEGO Movie 2: The Second Part makes a cameo as a keychain on Professor Utonium’s car keys.
 * The Mystery Machine from Scoob! makes a cameo appearance parked near the Derbytantes’ lair.
 * Pete from Space Jam: A New Legacy makes a cameo appearance as a hanging accessory on the mirror on one of the vehicles.
 * Blackberry Cookie and Onion Cookie from the untitled Cookie Run film appear as one of Bubbles’ figurines.
 * Red, Chuck, Bomb, and Silver from The Angry Birds Movie 3 appear as plush toys in the Powerpuff Girls’ room.
 * A poster of The LEGO Movie can be seen in the 2014 Powerpuff Girls' house.
 * A scene from The LEGO Batman Movie can be shown on the screen of the Townsville Multiplex during the final battle scene.
 * Finn and Jake from the untitled Adventure Time film appear on one of the picture frames in the Utonium House.
 * Gumball and Darwin from the untitled Amazing World of Gumball film make cameo appearances on one of the picture frames in the Utonium House.
 * Unikitty, Puppycorn, Dr. Fox, Hawkodile, and Richard from the untitled UniKitty! film make a cameo appearance on one of the picture frames in the Utonium House.
 * A picture of the DC Super Hero Girls is seen on one of the picture frames in the Utonium House.

Sequel
Warner Animation Group confirmed that a sequel to The Powerpuff Girls Movie 2: Generations was in the early stages of development.

Follow-up television series
The Powerpuff Girls: Tales from the City of Townsville is an HBO Max and WarnerUniversal All Access original animated musical television series co-produced with Cartoon Network Studios. It is the sequel to the 2016 iteration of The Powerpuff Girls. The same collaborators of the 2016 reboot of The Powerpuff Girls will be involved with this new series, and the spin-offs. The series takes place after the events of the 2016 iteration of The Powerpuff Girls and the 2024 film The Powerpuff Girls Movie 2: Generations. The series was animated at Copernicus Studios and Bardel Entertainment in Canada, which also did the animation for the four spin-offs.

Set after the events of The Powerpuff Girls Movie 2: Generations, Blossom, Bubbles, Buttercup, and Blisstina: four girl superheroes have recently reduced crime and now live a normal life, although they still have their powers. Even so, they still save Townsville whenever they are needed. The Powerpuff Girls: Tales from the City of Townsville is the next chapter in the Powerpuff Girls’ adventures, and focuses on their everyday lives and musical adventures.

The series premiered on Cartoon Network, HBO Max, and WarnerUniversal All Access on May 28, 2025, the same day as The LEGO Series.

 It's Blossom!
It's Blossom! is an HBO Max and WarnerUniversal All Access original animated series produced by Cartoon Network Studios.

Blossom Powerpuff stars in her own show, with new songs, new friends, new life, and new fun video chats to have with real people and kids, and even teens!

Alongside The LEGO Series and The Powerpuff Girls: Tales from the City of Townsville, the series premiered on Cartoon Network, HBO Max, and WarnerUniversal All Access on May 28, 2025.

 Bubbles' World
Bubbles' World is a WarnerUniversal All Access original animated series produced by Cartoon Network Studios.

Bubbles’ World follows everyone’s favorite bubbly Powerpuff Girl at home in her room as she hosts an imaginary variety show that comes from the bizarre and hysterical depths of her own brain.

Alongside The LEGO Series, The Powerpuff Girls: Tales from the City of Townsville, and It's Blossom!, the series premiered on Cartoon Network and WarnerUniversal All Access on May 28, 2025.

Untitled spin-off television series starring Buttercup
The untitled spin-off television series starring Buttercup is an HBO Max and WarnerUniversal All Access original animated series produced by Cartoon Network Studios.

Not much is known about the new series, but what is known is that Buttercup will be voiced by Natalie Palamides.

Alongside The LEGO Series, The Powerpuff Girls: Tales from the City of Townsville, It's Blossom!, and Bubbles' World, the series premiered on Cartoon Network, HBO Max, and WarnerUniversal All Access on May 28, 2025.

Blisstina's Club
Blisstina's Club is an HBO Max and WarnerUniversal All Access original animated series produced by Cartoon Network Studios.

Is there anyone who can say they never wished they could be a fly on the wall inside their idols’ homes? Particularly when we’re talking about Blisstina (voiced by Olivia Olson), the cutest and most dazzling popstar on the planet, and when the home in question is Bliss-Van, a super stylish party on-the-go during a world tour. A mobile home is just the thing for Blisstina, since no neighbor can stand the ruckus created by this crew of friends who approach every day like it’s a party. Good thing that Blisstina’s sisters are there to remind her about what really matters. Juggling domestic issues, spectacular shows and epic drama, Blisstina’s set to find out that being with those you care about is the best part of any trip.

Alongside The LEGO Series, The Powerpuff Girls: Tales from the City of Townsville, It's Blossom!, Bubbles' World, and the untitled spin-off television series starring Buttercup, the series premiered on Cartoon Network, HBO Max, and WarnerUniversal All Access on May 28, 2025.

The Powerpuff Girls (1998) revival
Cartoon Network even confirmed that the original Powerpuff Girls series will get a revival, even with the original cast returning instead of the 2016 cast, according to Tara Strong and E.G. Daily, the original actresses for Bubbles and Buttercup. The series premiered on Cartoon Network and HBO Max on May 28, 2025, the same day The LEGO Series, The Powerpuff Girls: Tales from the City of Townsville, It's Blossom!, and Bubbles' World premieres. It not only continues the storyline from where the original series left off, it also takes place after the events of The Powerpuff Girls Movie 2: Generations.

Transcript
Main article: The Powerpuff Girls Movie 2: Generations/Transcript